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KMID : 0371320070730010027
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Journal of the Korean Surgical Society
2007 Volume.73 No. 1 p.27 ~ p.30
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Correlation of the Lewis Blood Group and the CEA Serum Level in Stomach Cancer Patients
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Ryu Dong-Won
Lee Sang-Ho
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Abstract
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Purpose: The purpose of our study was to compare the serum levels of CEA, CA19-9 and H.pylori antibody in patients with the Lewis (a+) blood group with that of the patients with the Lewis (a??) blood group. We also compared the outcome of the stomach cancer patients with the Lewis (b+) blood group with that of the stomach cancer patients with the
Lewis (b??) blood group.
Methods: All of the 94 patients who underwent gastrectomy for stomach cancer at our hospital were retrospectively reviewed. The outcomes of the CEA, CA19-9 and H.pylori. antibody serum levels, the TNM stage, the ABO blood group and the Rh blood group were compared between the patients with the Lewis blood groups (a+) and (a??) and the patients with the Lewis blood groups (b+) and (b??), respectively.
Results: The mean serum level of CEA between the patients with the Lewis blood group (a+) and (a??) showed a statistical correlation (mean value: 5.51 ng/ml vs 3.25 ng/ml, respectively, P=0.016). But the mean serum level of CA19-9
and H.pylori. antibodies between the patients with the Lewis blood group (a+) and (a??) did not show a significant difference. The mean serum levels of CEA, CA19-9 and H.pylori antibodies between the patients with the Lewis blood
group (b+) and (b??) did not show a significant difference.
Conclusion: It was revealed that an elevated CEA level was related with the Lewis blood group (a), but this was not related with the Lewis blood group (b) in stomach cancer patients.
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KEYWORD
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Lewis blood group, Gastric cancer, CEA
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